DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …

DNA topoisomerases are enzymes that control the topology of DNA in all cells. There are
two types, I and II, classified according to whether they make transient single-or double …

Apoptosis is often accompanied by degradation of chromosomal DNA. CAD, caspase-
activated DNase, was identified in 1998 as a DNase that is responsible for this process. In …

Genotoxic therapy such as radiation serves as a frontline cancer treatment, yet acquired
resistance that leads to tumor reoccurrence is frequent. We found that cancer cells maintain …

Two classes of nucleases degrade the cellular DNA during apoptosis. Cell-autonomous
nucleases cleave DNA within the dying cell. They are not essential for apoptotic cell death or …

Nuclear apoptosis is characterized by chromatin condensation and progressive DNA
cleavage into high-molecular-weight fragments and oligonucleosomes. These complex …

Toward the end of the 20th and beginning of the 21st centuries, clever in vitro biochemical
complementation experiments and genetic screens from the laboratories of Xiaodong Wang …

Topoisomerase inhibitors are among the most efficient inducers of apoptosis. The main
pathways leading from topoisomerase-mediated DNA damage to cell death involve …

Background: Histone deacetylase inhibitors (HDACi) can sensitise cancer cells to
topoisomerase inhibitors by increasing their access and binding to DNA. Methods: This …

Recurring chromosome abnormalities are strongly associated with certain subtypes of
leukemia, lymphoma and sarcomas. More recently, their potential involvement in …