Automated Efficient Estimation using Monte Carlo Efficient Influence Functions

R Agrawal, S Witty, A Zane, E Bingham - arXiv preprint arXiv:2403.00158, 2024 - arxiv.org
Many practical problems involve estimating low dimensional statistical quantities with high-
dimensional models and datasets. Several approaches address these estimation tasks …

Adaptive-TMLE for the Average Treatment Effect based on Randomized Controlled Trial Augmented with Real-World Data

M van der Laan, S Qiu, L van der Laan - arXiv preprint arXiv:2405.07186, 2024 - arxiv.org
We consider the problem of estimating the average treatment effect (ATE) when both
randomized control trial (RCT) data and real-world data (RWD) are available. We …

A double machine learning approach to combining experimental and observational data

H Parikh, M Morucci, V Orlandi, S Roy, C Rudin… - arXiv preprint arXiv …, 2023 - arxiv.org
Experimental and observational studies often lack validity due to untestable assumptions.
We propose a double machine learning approach to combine experimental and …

Many Data: Combine Experimental and Observational Data through a Power Likelihood

X Lin, RJ Evans - arXiv preprint arXiv:2304.02339, 2023 - arxiv.org
Randomized controlled trials are commonly regarded as the gold standard for causal
inference and play a pivotal role in modern evidence-based medicine. However, the sample …

Understanding the risks and rewards of combining unbiased and possibly biased estimators, with applications to causal inference

M Oberst, A D'Amour, M Chen, Y Wang… - arXiv preprint arXiv …, 2022 - arxiv.org
Several problems in statistics involve the combination of high-variance unbiased estimators
with low-variance estimators that are only unbiased under strong assumptions. A notable …

Enhancing Statistical Validity and Power in Hybrid Controlled Trials: A Randomization Inference Approach with Conformal Selective Borrowing

K Zhu, S Yang, X Wang - arXiv preprint arXiv:2410.11713, 2024 - arxiv.org
Randomized controlled trials (RCTs) are the gold standard for causal inference but may lack
power because of small populations in rare diseases and limited participation in common …

Case study of semaglutide and cardiovascular outcomes: An application of the Causal Roadmap to a hybrid design for augmenting an RCT control arm with real-world …

LE Dang, E Fong, JM Tarp… - Journal of Clinical and …, 2023 - cambridge.org
Introduction: Increasing interest in real-world evidence has fueled the development of study
designs incorporating real-world data (RWD). Using the Causal Roadmap, we specify three …

Efficient combination of observational and experimental datasets under general restrictions on outcome mean functions

HH Li - arXiv preprint arXiv:2406.06941, 2024 - arxiv.org
A researcher collecting data from a randomized controlled trial (RCT) often has access to an
auxiliary observational dataset that may be confounded or otherwise biased for estimating …

A Causal Roadmap for Hybrid Randomized and Real-World Data Designs: Case Study of Semaglutide and Cardiovascular Outcomes

LE Dang, E Fong, JM Tarp, KKB Clemmensen… - arXiv preprint arXiv …, 2023 - arxiv.org
Introduction: Increasing interest in real-world evidence has fueled the development of study
designs incorporating real-world data (RWD). Using the Causal Roadmap, we specify three …

Covariate Adjustment in Modern Causal Design and Analysis

LD Liao - 2024 - search.proquest.com
Clinicians, policymakers, psychologists, and economists often ask causal questions: does
this treatment or intervention cause the observed differences in outcome? If researchers can …