Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals

CM Ripplinger, AV Glukhov, MW Kay… - American Journal …, 2022 - journals.physiology.org
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Characteristics of bisphenol cardiotoxicity: impaired excitability, contractility, and relaxation

BL Cooper, NG Posnack - Cardiovascular toxicology, 2022 - Springer
Bisphenol a (BPA) is a high production volume chemical that is frequently used to
manufacture epoxy resins and polycarbonate plastics. BPA-containing products are now …

High resolution optical mapping of cardiac electrophysiology in pre-clinical models

C O'Shea, J Winter, SN Kabir, M O'Reilly, SP Wells… - Scientific Data, 2022 - nature.com
Optical mapping of animal models is a widely used technique in pre-clinical cardiac
research. It has several advantages over other methods, including higher spatial resolution …

The effect of sex and age on ex vivo cardiac electrophysiology: insight from a guinea pig model

KT Haq, BL Cooper, F Berk… - American Journal of …, 2023 - journals.physiology.org
Highlighting the importance of sex as a biological variable, we recently reported sex
differences in guinea pig in vivo electrocardiogram (ECG) measurements. However …

Diversity of cells and signals in the cardiovascular system

E Grandi, MF Navedo, JJ Saucerman… - The Journal of …, 2023 - Wiley Online Library
This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes

BL Cooper, S Salameh, NG Posnack - Toxicological Sciences, 2024 - academic.oup.com
Bisphenol A (BPA) is commonly used to manufacture consumer and medical-grade plastics.
Due to health concerns, BPA substitutes are being incorporated—including bisphenol S …

Evidence for the cardiodepressive effects of the plasticizer di-2-ethylhexyl phthalate

LM Swift, A Roberts, J Pressman… - Toxicological …, 2024 - academic.oup.com
Abstract Di-2-ethylhexyl phthalate (DEHP) is commonly used in the manufacturing of plastic
materials, including intravenous bags, blood storage bags, and medical-grade tubing. DEHP …

[HTML][HTML] Multifactorial approaches to enhance maturation of human iPSC-derived cardiomyocytes

K Kistamás, A Müller, S Muenthaisong… - Journal of Molecular …, 2023 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

[HTML][HTML] KairoSight-3.0: A validated optical mapping software to characterize cardiac electrophysiology, excitation-contraction coupling, and alternans

KT Haq, A Roberts, F Berk, S Allen, LM Swift… - Journal of molecular and …, 2023 - Elsevier
Background Cardiac optical mapping is an imaging technique that measures fluorescent
signals across a cardiac preparation. Dual optical imaging of voltage-sensitive and calcium …

Demographic and methodological heterogeneity in electrocardiogram signals from guinea pigs

KT Haq, BL Cooper, F Berk, A Roberts, LM Swift… - Frontiers in …, 2022 - frontiersin.org
Electrocardiograms (ECG) are universally used to measure the electrical activity of the heart;
however, variations in recording techniques and/or subject demographics can affect ECG …