The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses
recognition memory. Recognition memory is disturbed in a range of human disorders and …

Comprehensive behavioral analyses of transgenic and knockout mice have successfully
identified the functional roles of many genes in the brain. Over the past 10 years, strategies …

Background The correlation between neurofibrillary tangles of tau and disease progression
in the brains of Alzheimer's disease (AD) patients remains an area of contention. Innovative …

Inability to form new memories is an early clinical sign of Alzheimer's disease (AD). There is
ample evidence that the amyloid-β (Aβ) peptide plays a key role in the pathogenesis of this …

The amyloid-β peptide Aβ42 is known to be a primary amyloidogenic and pathogenic agent
in Alzheimer's disease. However, the role of Aβ43, which is found just as frequently in the …

Amyloid precursor protein (APP) proteolysis is required for production of amyloid-β (Aβ)
peptides that comprise β-amyloid plaques in brains of Alzheimer's disease (AD) patients …

Cognitive decline in Alzheimer's disease (AD) involves pathological accumulation of
synaptotoxic amyloid-β (Aβ) oligomers and hyperphosphorylated tau. Because recent …

We have reported that hydrogen (H 2) acts as an efficient antioxidant by gaseous rapid
diffusion. When water saturated with hydrogen (hydrogen water) was placed into the …

• Introduction• Innate immune response in the AD brain‐Microglia‐Astrocyte• Glial cells
mediate the peripheral immune response in AD‐Glial cell interaction with endothelial cells …

" Nutraceuticals" are well-tolerated natural dietary compounds with drug-like properties that
make them attractive as Alzheimer's disease (AD) therapeutics. Combination therapy for AD …