Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …

The plasma coagulation system in mammalian blood consists of a cascade of enzyme
activation events in which serine proteases activate the proteins (proenzymes and …

Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

The release of histones from dying cells is associated with microvascular thrombosis and,
because histones activate platelets, this could represent a possible pathogenic mechanism …

The contact system is a plasma protease cascade initiated by factor XII (FXII) that activates
the proinflammatory kallikrein‐kinin system and the procoagulant intrinsic coagulation …

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

The formation of fibrin clots that are relatively resistant to lysis represents the final step in
blood coagulation. We discuss the genetic and environmental regulators of fibrin structure in …

Venous thrombosis is a leading cause of morbidity and mortality in industrialized countries,
especially in the elderly. Many risk factors have been identified for venous thrombosis that …

Composed of up to 1,000 phospho-anhydride bond-linked phosphate monomers, inorganic
polyphosphate (polyP) is one of the most ancient, conserved, and enigmatic molecules in …