The integrated stress response

K Pakos‐Zebrucka, I Koryga, K Mnich, M Ljujic… - EMBO …, 2016 - embopress.org
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Metabolic reprogramming in glioma

M Strickland, EA Stoll - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …

Prediction of risk for myeloid malignancy in clonal hematopoiesis

LD Weeks, A Niroula, D Neuberg, W Wong… - NEJM …, 2023 - evidence.nejm.org
Background Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of
undetermined significance (CCUS) are defined by somatic mutations in genes associated …

[HTML][HTML] Distinction of lymphoid and myeloid clonal hematopoiesis

A Niroula, A Sekar, MA Murakami, M Trinder… - Nature medicine, 2021 - nature.com
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …

Genome sequencing as an alternative to cytogenetic analysis in myeloid cancers

EJ Duncavage, MC Schroeder… - … England Journal of …, 2021 - Mass Medical Soc
Background Genomic analysis is essential for risk stratification in patients with acute myeloid
leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a …

MarkerDB: an online database of molecular biomarkers

DS Wishart, B Bartok, E Oler, KYH Liang… - Nucleic acids …, 2021 - academic.oup.com
MarkerDB is a freely available electronic database that attempts to consolidate information
on all known clinical and a selected set of pre-clinical molecular biomarkers into a single …

[HTML][HTML] Recurrent rearrangements in PRKACA and PRKACB in intraductal oncocytic papillary neoplasms of the pancreas and bile duct

AD Singhi, LD Wood, E Parks, MS Torbenson… - Gastroenterology, 2020 - Elsevier
Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …

Ultra-high mass resolution MALDI imaging mass spectrometry of proteins and metabolites in a mouse model of glioblastoma

M Dilillo, R Ait-Belkacem, C Esteve, D Pellegrini… - Scientific reports, 2017 - nature.com
MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …

The 2012 nucleic acids research database issue and the online molecular biology database collection

MY Galperin, XM Fernández-Suarez - Nucleic acids research, 2012 - academic.oup.com
Abstract The 19th annual Database Issue of Nucleic Acids Research features descriptions of
92 new online databases covering various areas of molecular biology and 100 papers …

The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours

R El Ansari, ML Craze, I Miligy, M Diez-Rodriguez… - Breast Cancer …, 2018 - Springer
Background Breast cancer (BC) is a heterogeneous disease characterised by variant
biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC …