The integrated stress response
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …
Metabolic reprogramming in glioma
M Strickland, EA Stoll - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …
Prediction of risk for myeloid malignancy in clonal hematopoiesis
Background Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of
undetermined significance (CCUS) are defined by somatic mutations in genes associated …
undetermined significance (CCUS) are defined by somatic mutations in genes associated …
[HTML][HTML] Distinction of lymphoid and myeloid clonal hematopoiesis
Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal
expansion of blood cells. Somatic gene mutations associated with hematologic …
expansion of blood cells. Somatic gene mutations associated with hematologic …
Genome sequencing as an alternative to cytogenetic analysis in myeloid cancers
EJ Duncavage, MC Schroeder… - … England Journal of …, 2021 - Mass Medical Soc
Background Genomic analysis is essential for risk stratification in patients with acute myeloid
leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a …
leukemia (AML) or myelodysplastic syndromes (MDS). Whole-genome sequencing is a …
MarkerDB: an online database of molecular biomarkers
DS Wishart, B Bartok, E Oler, KYH Liang… - Nucleic acids …, 2021 - academic.oup.com
MarkerDB is a freely available electronic database that attempts to consolidate information
on all known clinical and a selected set of pre-clinical molecular biomarkers into a single …
on all known clinical and a selected set of pre-clinical molecular biomarkers into a single …
[HTML][HTML] Recurrent rearrangements in PRKACA and PRKACB in intraductal oncocytic papillary neoplasms of the pancreas and bile duct
Background & Aims Intraductal oncocytic papillary neoplasms (IOPNs) of the pancreas and
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …
bile duct contain epithelial cells with numerous, large mitochondria and are cystic precursors …
Ultra-high mass resolution MALDI imaging mass spectrometry of proteins and metabolites in a mouse model of glioblastoma
M Dilillo, R Ait-Belkacem, C Esteve, D Pellegrini… - Scientific reports, 2017 - nature.com
MALDI mass spectrometry imaging is able to simultaneously determine the spatial
distribution of hundreds of molecules directly from tissue sections, without labeling and …
distribution of hundreds of molecules directly from tissue sections, without labeling and …
The 2012 nucleic acids research database issue and the online molecular biology database collection
MY Galperin, XM Fernández-Suarez - Nucleic acids research, 2012 - academic.oup.com
Abstract The 19th annual Database Issue of Nucleic Acids Research features descriptions of
92 new online databases covering various areas of molecular biology and 100 papers …
92 new online databases covering various areas of molecular biology and 100 papers …
The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours
R El Ansari, ML Craze, I Miligy, M Diez-Rodriguez… - Breast Cancer …, 2018 - Springer
Background Breast cancer (BC) is a heterogeneous disease characterised by variant
biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC …
biology and patient outcome. The amino acid transporter, SLC7A5, plays a role in BC …