HIV-1 integrase inhibitors: a comparative review of efficacy and safety

KK Scarsi, JP Havens, AT Podany, SN Avedissian… - Drugs, 2020 - Springer
The newest class of antiretrovirals for all persons living with HIV are the integrase strand
transfer inhibitors (INSTIs). Since 2007, five INSTIs have been introduced: raltegravir …

[PDF][PDF] Neuropsychiatric adverse events with dolutegravir and other integrase strand transfer inhibitors.

C Hoffmann, JM Llibre - AIDS reviews, 2019 - academia.edu
Neuropsychiatric adverse events (NPAEs) observed with the integrase strand transfer
inhibitor (INSTI) dolutegravir (DTG) are usually mild to moderate. The most prevalent …

Integrase inhibitors: after 10 years of experience, is the best yet to come?

KM Brooks, EM Sherman, EF Egelund… - … : The Journal of …, 2019 - Wiley Online Library
The era of the integrase strand transfer inhibitors (INSTI s) for the treatment of human
immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time …

Comparative clinical pharmacokinetics and pharmacodynamics of HIV-1 integrase strand transfer inhibitors: an updated review

AT Podany, KK Scarsi, MM Pham, CV Fletcher - Clinical pharmacokinetics, 2020 - Springer
Abstract Bictegravir, cabotegravir, dolutegravir, elvitegravir, and raltegravir are members of
the latest class of antiretrovirals available to treat human immunodeficiency virus (HIV) …

Plasma Human Immunodeficiency Virus 1 RNA and CD4+ T-Cell Counts Are Determinants of Virological Nonsuppression Outcomes With Initial Integrase Inhibitor …

H Álvarez, A Mocroft, L Ryom… - Clinical Infectious …, 2023 - academic.oup.com
Background There are conflicting data regarding baseline determinants of virological
nonsuppression outcomes in persons with human immunodeficiency virus (HIV) starting …

[HTML][HTML] A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection

AV Zhao, RD Crutchley, RC Guduru, K Ton, T Lam… - Retrovirology, 2022 - Springer
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human
immunodeficiency virus (HIV). There are currently four approved for use in treatment-naïve …

Contribution of low CD4 cell counts and high human immunodeficiency virus (HIV) viral load to the efficacy of preferred first-line antiretroviral regimens for treating HIV …

JA Perez-Molina, C Crespillo-Andújar… - Clinical Infectious …, 2023 - academic.oup.com
We assessed whether low CD4 count and high viral load (VL) affect the response to
currently preferred ART. We performed a systematic review of randomized, controlled …

Plasma HIV-1 RNA and CD4⁺ T-cell counts are determinants of virological non-suppression outcomes with initial integrase inhibitor-based regimens: A prospective …

H Álvarez, A Mocroft, L Ryom… - Clinical Infectious …, 2023 - discovery.ucl.ac.uk
BACKGROUND: There are conflicting data regarding baseline determinants of virological
non-suppression outcomes in persons with HIV who initiate antiretroviral treatment (ART) …

Integrase inhibitors: current protagonists in antiretroviral therapy

JD Loaiza, M Chvatal-Medina, JC Hernandez… - …, 2023 - Taylor & Francis
Since HIV was identified as the etiological agent of AIDS, there have been significant
advances in antiretroviral therapy (ART) that has reduced morbidity/mortality. Still, the viral …

[PDF][PDF] Dolutegravir neuropsychiatric adverse events: specific drug effect or class effect

JC Yombi - AIDS Rev, 2018 - dial.uclouvain.be
Integrase strand transfer inhibitors (INSTIs) are a newer class of antiretroviral treatment for
HIV-infected patient. INSTIs currently available for use are raltegravir, elvitegravir …