The ovarian follicle provides the oocyte with the ideal environment for growth and
development in preparation for ovulation and fertilisation. The follicle undergoes many …

Granulosa cells (GCs) are somatic cells essential for establishing and maintaining bi-
directional communication with the oocytes. This connection has a profound importance for …

Abstract Microplastics (MPs) and nanoplastics (NPs) are widely found in water, food and air,
and have been found in human blood, lung and feces. Several studies in vivo have shown …

Granulosa cells are crucial for the establishment and maintenance of bidirectional
communication among oocytes. Various intercellular material exchange modes, including …

For decades, the undisputable definition of the cytosolic Hsp90α and hsp90β proteins being
evolutionarily conserved, ATP-driven chaperones has ruled basic research and clinical …

Frozen-thawed human ovarian tissue endures large-scale follicle loss in the early post-
grafting period, characterized by hypoxia lasting around 7 days. Tissue revascularization …

The number of (TTAGGG) n repeats at the ends of chromosomes is highly variable between
individual chromosomes, between different cells and between species. Progressive loss of …

Reactive oxygen species (ROS) produced by NADPH1 oxidase 1 (NOX1) are thought to
drive spermatogonial stem cell (SSC) self-renewal through feed-forward production of ROS …

Abstract Hypoxia-inducible factor-1 (HIF-1), a master transcriptional factor for protecting cells
from hypoxia, plays a critical role in spermatogenesis and tumorigenesis. For the past two …

In female reproduction, the oocyte number is limited after birth. To achieve a continuous
ovulatory cycle, oocytes are stored in primordial follicles. Therefore, the regulation of …