The blood-brain barrier (BBB) constitutes the interface between the blood and the brain
tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain …

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming
growth factor (TGF)-β family of ligands and exert most of their effects through the canonical …

Human pluripotent stem cell (hPSC)-derived endothelial cells and their progenitors may
provide the means for vascularization of tissue-engineered constructs and can serve as …

Previous efforts to differentiate human embryonic stem cells (hESCs) into endothelial cells
have not achieved sustained expansion and stability of vascular cells. To define …

Here, we report the derivation of arterial endothelial cells from human pluripotent stem cells
that exhibit arterial-specific functions in vitro and in vivo. We combine single-cell RNA …

Background Heterogeneity of endothelial cells (ECs) is a hallmark of the vascular system
which may impact the development and management of vascular disorders. Despite the …

Fibroblasts can be directly reprogrammed into cardiomyocytes, endothelial cells or smooth
muscle cells. Here we report the reprogramming of mouse tail-tip fibroblasts simultaneously …

Bone morphogenetic proteins (BMPs) initiate differentiation in human embryonic stem cells
(hESCs) but the exact mechanisms have not been fully elucidated. We demonstrate here …

Human pluripotent stem cell (hPSC)-derived endothelial lineage cells constitutes a
promising source for therapeutic revascularization, but progress in this arena has been …

The aryl hydrocarbon receptor (AHR) plays an important physiological role in
hematopoiesis. AHR is highly expressed in hematopoietic stem and progenitor cells …