Recent scientific evidence has shown the importance of diet and lifestyle habits for the
proper functioning of the human body. A balanced and healthy diet, physical activity, and …

The molecular signatures of epigenetic regulation and chromatin architecture are emerging
as pivotal regulators of mitochondrial function. Recent studies unveiled a complex …

It has been reported that long non-coding RNA HOXA distal transcript antisense RNA
(lncRNA HOTTIP) functions as a tumor promoter in colorectal cancer (CRC). Hence, we paid …

Recent developments in the field of genetics have accelerated our understanding of the
aetiology of complex diseases. Type 2 diabetes mellitus and cancer are no exception, with …

Mounting epidemiological evidence indicates that environmental exposures in early life
have roles in diabetes susceptibility in later life. Additionally, environmentally induced …

Adipose tissue dysfunction, particularly the visceral (VAT) compartment, has been proposed
to play a relevant role in colorectal cancer (CRC) development and progression. Epigenetic …

There has been great interest in genetic risk prediction using risk scores in recent years,
however, the utility of scores developed in European populations and later applied to non …

Obesity is a modifiable risk factor of breast cancer and epigenetic marks were proposed as a
relevant mechanistic link. These mechanisms can be remodelled by modifying lifestyle …

As a pluripotent cell, activated pancreatic stellate cells (PSCs) can differentiate into various
pancreatic parenchymal cells and participate in the secretion of extracellular matrix and the …

Emerging evidence suggests the growing importance of “nongenetic factors” in the
pathogenesis of atherosclerotic vascular disease. Indeed, the inherited genome determines …