Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

Most prostate cancers are androgen-sensitive malignancies whose growths depend on the
transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins …

Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

Androgen receptor (AR) is a ligand-dependent transcription factor that plays a key role in
prostate cancer. Little is known about the nature of AR cis-regulatory sites in the human …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Androgens and mesenchymal factors are essential extracellular signals for the development
as well as the functional activity of the prostate epithelium. Little is known of the …

Mutations in the androgen receptor (AR) that enable activation by antiandrogens occur in
hormone-refractory prostate cancer, suggesting that mutant ARs are selected by treatment …

Normal and neoplastic growth of the prostate gland are dependent on androgen receptor
(AR) expression and function. Androgenic activation of the AR, in association with its …

Elucidating the determinants of aggressiveness in lethal prostate cancer may stimulate
therapeutic strategies that improve clinical outcomes. We used experimental models and …

FOXA transcription factors are potent, context‐specific mediators of development that hold
specialized functions in hormone‐dependent tissues. Over the last several years, FOXA1 …