The Role of Chemokines in the Pathogenesis of HTLV-1

R Zargari, M Mahdifar, A Mohammadi… - Frontiers in …, 2020 - frontiersin.org
Human T cell leukemia virus type 1 (HTLV-1) is a human retrovirus that is associated with
two main diseases: HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) …

HTLV-1 infection of myeloid cells: from transmission to immune alterations

B Rocamonde, A Carcone, R Mahieux, H Dutartre - Retrovirology, 2019 - Springer
Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell
leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as …

NK cells and monocytes modulate primary HTLV-1 infection

R Moles, S Sarkis, V Galli, M Omsland, M Artesi… - PLoS …, 2022 - journals.plos.org
We investigated the impact of monocytes, NK cells, and CD8+ T-cells in primary HTLV-1
infection by depleting cell subsets and exposing macaques to either HTLV-1 wild type …

Human T cell leukemia virus type 1 infection of the three monocyte subsets contributes to viral burden in humans

MF de Castro-Amarante, CA Pise-Masison… - Journal of …, 2016 - Am Soc Microbiol
Because the viral DNA burden correlates with disease development, we investigated the
contribution of monocyte subsets (classical, intermediate, and nonclassical monocytes) to …

The Role of NK Cells in the Control of Viral Infection in HTLV‐1 Carriers

CF Amorim, NB Carvalho, JA Neto… - Journal of …, 2019 - Wiley Online Library
The cytotoxic activities of CD8+ T cells have been considered the main defense mechanism
against the human T lymphotropic virus type 1 (HTLV‐1). As with CD8+ T cells, NK cells can …

NF-κB1 deficiency promotes macrophage-derived adrenal tumors but decreases neurofibromas in HTLV-I LTR-Tax transgenic mice

X Song, Z Qu - Plos one, 2024 - journals.plos.org
Human T-cell leukemia virus type I (HTLV-I) is an oncogenic virus whose infection can
cause diverse diseases, most notably adult T-cell leukemia/lymphoma (ATL or ATLL), an …

[HTML][HTML] Monocyte and Macrophage Functions in Oncogenic Viral Infections

J Echevarria-Lima, R Moles - Viruses, 2024 - mdpi.com
Monocytes and macrophages are part of innate immunity and constitute the first line of
defense against pathogens. Bone marrow-derived monocytes circulate in the bloodstream …

HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice

R Ginwala, B Caruso, ZK Khan, A Pattekar… - Journal of Neuroimmune …, 2017 - Springer
To date, the lack of a suitable small animal model has hindered our understanding of
Human T-cell lymphotropic virus (HTLV)-1 chronic infection and associated …

TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals

M Guerra, NB Carvalho, S Santos… - Frontiers in …, 2022 - frontiersin.org
HTLV-1-infected individuals may develop a neurologic inflammatory condition known as
HTLV-1-associated myelopathy (HAM/TSP), in which the high production of TNF is …

ITGAM-macrophage modulation as a potential strategy for treating neutrophilic Asthma: insights from bioinformatics analysis and in vivo experiments

Q Yan, Z Liu, Y Chen, X Zhang, W Zheng, X Liu… - Apoptosis, 2024 - Springer
Identification of molecular biomarkers associated with neutrophilic asthma (NA) phenotype
may inform the discovery of novel pathobiological mechanisms and the development of …