Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle
JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …
Brain glucose metabolism: integration of energetics with function
GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …
including ATP production, oxidative stress management, and synthesis of neurotransmitters …
The restless brain: how intrinsic activity organizes brain function
ME Raichle - … Transactions of the Royal Society B …, 2015 - royalsocietypublishing.org
Traditionally studies of brain function have focused on task-evoked responses. By their very
nature such experiments tacitly encourage a reflexive view of brain function. While such an …
nature such experiments tacitly encourage a reflexive view of brain function. While such an …
[HTML][HTML] Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
[HTML][HTML] Two views of brain function
ME Raichle - Trends in cognitive sciences, 2010 - cell.com
Traditionally studies of brain function have focused on task-evoked responses. By their very
nature, such experiments tacitly encourage a reflexive view of brain function. Although such …
nature, such experiments tacitly encourage a reflexive view of brain function. Although such …
Brain work and brain imaging
ME Raichle, MA Mintun - Annu. Rev. Neurosci., 2006 - annualreviews.org
Functional brain imaging with positron emission tomography and magnetic resonance
imaging has been used extensively to map regional changes in brain activity. The signal …
imaging has been used extensively to map regional changes in brain activity. The signal …
The glutamate/GABA‐glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
LK Bak, A Schousboe… - Journal of …, 2006 - Wiley Online Library
Neurons are metabolically handicapped in the sense that they are not able to perform de
novo synthesis of neurotransmitter glutamate and γ‐aminobutyric acid (GABA) from glucose …
novo synthesis of neurotransmitter glutamate and γ‐aminobutyric acid (GABA) from glucose …
Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
F Hyder, DL Rothman… - Proceedings of the …, 2013 - National Acad Sciences
The continuous need for ion gradient restoration across the cell membrane, a prerequisite
for synaptic transmission and conduction, is believed to be a major factor for brain's high …
for synaptic transmission and conduction, is believed to be a major factor for brain's high …
Highly energized inhibitory interneurons are a central element for information processing in cortical networks
O Kann, IE Papageorgiou… - Journal of Cerebral …, 2014 - journals.sagepub.com
Gamma oscillations (~ 30 to 100 Hz) provide a fundamental mechanism of information
processing during sensory perception, motor behavior, and memory formation by …
processing during sensory perception, motor behavior, and memory formation by …
Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
L Hertz, L Peng, GA Dienel - Journal of Cerebral Blood Flow …, 2007 - journals.sagepub.com
Astrocytic energy demand is stimulated by K+ and glutamate uptake, signaling processes,
responses to neurotransmitters, Ca2+ fluxes, and filopodial motility. Astrocytes derive energy …
responses to neurotransmitters, Ca2+ fluxes, and filopodial motility. Astrocytes derive energy …