The crosstalk among TLR2, TLR4 and pathogenic pathways; a treasure trove for treatment of diabetic neuropathy
Diabetes is correlated with organ failures as a consequence of microvascular diabetic
complications, including neuropathy, nephropathy, and retinopathy. These difficulties come …
complications, including neuropathy, nephropathy, and retinopathy. These difficulties come …
Neuropathic pain in multiple sclerosis and its animal models: focus on mechanisms, knowledge gaps and future directions
E Mirabelli, S Elkabes - Frontiers in Neurology, 2021 - frontiersin.org
Multiple sclerosis (MS) is a multifaceted, complex and chronic neurological disease that
leads to motor, sensory and cognitive deficits. MS symptoms are unpredictable and …
leads to motor, sensory and cognitive deficits. MS symptoms are unpredictable and …
Ginsenoside Rh2 inhibits NLRP3 inflammasome activation and improves exosomes to alleviate hypoxia-induced myocardial injury
Z Qi, Z Yan, Y Wang, N Ji, X Yang, A Zhang… - Frontiers in …, 2022 - frontiersin.org
The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting
factor in the clinical application of stem cell transplantation and paracrine exosome therapy …
factor in the clinical application of stem cell transplantation and paracrine exosome therapy …
Neuroprotection impact of biochanin A against pentylenetetrazol-kindled mice: targeting NLRP3 inflammasome/TXNIP pathway and autophagy modulation
Recurrent seizures characterize epilepsy, a complicated and multifaceted neurological
disease. Several neurological alterations, such as cell death and the growth of gorse fibers …
disease. Several neurological alterations, such as cell death and the growth of gorse fibers …
[HTML][HTML] Memantine mitigates ROS/TXNIP/NLRP3 signaling and protects against mouse diabetic retinopathy: Histopathologic, ultrastructural and bioinformatic studies
Diabetic retinopathy (DRET) triggers vision loss in adults, however, little therapeutic options
are existing. Memantine is an anti-Alzheimer drug that antagonizes the activity of glutamate …
are existing. Memantine is an anti-Alzheimer drug that antagonizes the activity of glutamate …
Neuroprotective mechanism of Ajugarin-I against Vincristine-Induced neuropathic pain via regulation of Nrf2/NF-κB and Bcl2 signalling
Vincristine (VCR) is a well-known chemotherapeutic agent that frequently triggers
neuropathic pain. Ajugarin-I (Aju-I) isolated from Ajuga bracteosa exerts antioxidant, anti …
neuropathic pain. Ajugarin-I (Aju-I) isolated from Ajuga bracteosa exerts antioxidant, anti …
Glial cell reactivity and oxidative stress prevention in Alzheimer's disease mice model by an optimized NMDA receptor antagonist
J Companys-Alemany, AL Turcu, S Vázquez… - Scientific Reports, 2022 - nature.com
In Alzheimer's disease pathology, several neuronal processes are dysregulated by
excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic …
excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic …
Toll-like receptors (TLRs) and their potential therapeutic applications in diabetic neuropathy
One of the most common diabetic microvascular complications is diabetic neuropathy (DN).
Immune cell infiltration in the peripheral nerve system (PNS), myelin loss, Schwann cell …
Immune cell infiltration in the peripheral nerve system (PNS), myelin loss, Schwann cell …
The cellular senescence factor extracellular HMGB1 directly inhibits oligodendrocyte progenitor cell differentiation and impairs CNS remyelination
HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. HMGB1 is normally
localized to the nucleus, where it acts as a chromatin associated non-histone binding …
localized to the nucleus, where it acts as a chromatin associated non-histone binding …
High mobility group box protein (HMGB1): A potential therapeutic target for diabetic encephalopathy
UK Dash, D Mazumdar, S Singh - Molecular Neurobiology, 2024 - Springer
HMGB (high mobility group B) is one of the ubiquitous non-histone nuclear protein
superfamilies that make up the HMG (high mobility group) protein group. HMGB1 is involved …
superfamilies that make up the HMG (high mobility group) protein group. HMGB1 is involved …