The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …

Meiosis is the chromosomal foundation of reproduction, with errors in this important process
leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the …

Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in
chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing …

Mammalian oocytes are particularly error prone in segregating their chromosomes during
their two meiotic divisions. This results in the creation of an embryo that has inherited the …

An increase in intraovarian reactive oxygen species (ROS) has long been implicated in the
decline in oocyte quality associated with maternal ageing. Oxidative stress (OS)-induced …

In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially
lead to infertility and developmental disorders. However, there is little known about the …

Chromosome segregation errors during female meiosis are a leading cause of pregnancy
loss and human infertility. The segregation of chromosomes is driven by interactions …

BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …

The chromosomal program of meiotic prophase, comprising events such as laying down of
meiotic cohesins, synapsis between homologs, and homologous recombination, must be …