The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir
D Jochmans, C Liu, K Donckers, A Stoycheva… - MBio, 2023 - Am Soc Microbiol
The SARS-CoV-2 main protease (3CLpro) has an indispensable role in the viral life cycle
and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors …
and is a therapeutic target for the treatment of COVID-19. The potential of 3CLpro-inhibitors …
SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific
response has been rapid and effective, with many therapeutic monoclonal antibodies and …
response has been rapid and effective, with many therapeutic monoclonal antibodies and …
Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication
L Lin, DY Chen, C Scartelli, H Xie, G Merrill-Skoloff… - Iscience, 2023 - cell.com
Plant-based flavonoids have been evaluated as inhibitors of β-coronavirus replication and
as therapies for COVID-19 on the basis of their safety profile and widespread availability …
as therapies for COVID-19 on the basis of their safety profile and widespread availability …
Efficacy of late-onset antiviral treatment in immunocompromised hosts with persistent SARS-CoV-2 infection
CM Lieber, HJ Kang, EB Sobolik, ZM Sticher… - Journal of …, 2024 - journals.asm.org
Immunocompromised people are at high risk of prolonged severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection and progression to severe coronavirus …
syndrome coronavirus 2 (SARS-CoV-2) infection and progression to severe coronavirus …
Rapid resistance profiling of SARS-CoV-2 protease inhibitors
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already
exist in clinical SARS-CoV-2 isolates. Here a robust cell-based assay is used to determine …
exist in clinical SARS-CoV-2 isolates. Here a robust cell-based assay is used to determine …
A low-background, fluorescent assay to evaluate inhibitors of diverse viral proteases
RA Leonard, VN Rao, A Bartlett, HM Froggatt… - Journal of …, 2023 - Am Soc Microbiol
Multiple coronaviruses (CoVs) can cause respiratory diseases in humans. While
prophylactic vaccines designed to prevent infection are available for severe acute …
prophylactic vaccines designed to prevent infection are available for severe acute …
Drug susceptibility and the potential for drug-resistant SARS-CoV-2 emergence in immunocompromised animals
The reduced susceptibility of mRNA vaccines and diminished neutralizing activity of
therapeutic monoclonal antibodies against Omicron variants, including BQ. 1.1, XBB, and …
therapeutic monoclonal antibodies against Omicron variants, including BQ. 1.1, XBB, and …
Sequence analysis of the Spike, RNA-dependent RNA polymerase, and protease genes reveals a distinct evolutionary pattern of SARS-CoV-2 variants circulating in …
During the Covid-19 pandemic, the resurgence of SARS-CoV-2 was due to the development
of novel variants of concern (VOC). Thus, genomic surveillance is essential to monitor …
of novel variants of concern (VOC). Thus, genomic surveillance is essential to monitor …