Brain manganese and the balance between essential roles and neurotoxicity
RC Balachandran, S Mukhopadhyay, D McBride… - Journal of Biological …, 2020 - ASBMB
Manganese (Mn) is an essential micronutrient required for the normal development of many
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
organs, including the brain. Although its roles as a cofactor in several enzymes and in …
Sex-specific neurotoxic effects of heavy metal pollutants: Epidemiological, experimental evidence and candidate mechanisms
The heavy metals lead (Pb), mercury (Hg), and cadmium (Cd) are ubiquitous environmental
pollutants and are known to exert severe adverse impacts on the nervous system even at …
pollutants and are known to exert severe adverse impacts on the nervous system even at …
Manganese is essential for neuronal health
KJ Horning, SW Caito, KG Tipps… - Annual review of …, 2015 - annualreviews.org
The understanding of manganese (Mn) biology, in particular its cellular regulation and role
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
in neurological disease, is an area of expanding interest. Mn is an essential micronutrient …
Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
Manganese: recent advances in understanding its transport and neurotoxicity
The present review is based on presentations from the meeting of the Society of Toxicology
in San Diego, CA (March 2006). It addresses recent developments in the understanding of …
in San Diego, CA (March 2006). It addresses recent developments in the understanding of …
Associations of a metal mixture measured in multiple biomarkers with IQ: evidence from Italian adolescents living near ferroalloy industry
Background: Research on the health effects of chemical mixtures has focused mainly on
early life rather than adolescence, a potentially important developmental life stage …
early life rather than adolescence, a potentially important developmental life stage …
Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity
AD Kraft, GJ Harry - International journal of environmental research and …, 2011 - mdpi.com
Microglia are resident cells of the brain involved in regulatory processes critical for
development, maintenance of the neural environment, injury and repair. They belong to the …
development, maintenance of the neural environment, injury and repair. They belong to the …
Manganese and Parkinson's disease: a critical review and new findings
TR Guilarte - Environmental health perspectives, 2010 - ehp.niehs.nih.gov
Background Excess accumulation of manganese (Mn) in the brain results in a neurological
syndrome with cognitive, psychiatric, and movement abnormalities. The highest …
syndrome with cognitive, psychiatric, and movement abnormalities. The highest …
SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity
Manganese (Mn) is an essential metal, but elevated cellular levels are toxic and may lead to
the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn …
the development of an irreversible parkinsonian-like syndrome that has no treatment. Mn …
Manganese exposure from drinking water and children's academic achievement
Drinking water manganese (WMn) is a potential threat to children's health due to its
associations with a wide range of outcomes including cognitive, behavioral and …
associations with a wide range of outcomes including cognitive, behavioral and …