Background: There is a growing liberalization of cannabis-based preparations for medical
and recreational use. In multiple instances, anxiety and depression are cited as either a …

In this review article, we embark on a thorough exploration of cannabinoids, compounds that
have garnered considerable attention for their potential therapeutic applications. Initially, this …

Evidence suggests that the accumulation of lipid drots (LDs) accelerates damage to
mitochondria and increases the release of inflammatory factors. These have been implicated …

The accumulation of amyloid-β (Aβ) peptides in the brain is considered to be the initial event
in the Alzheimer's disease (AD). Neurotoxicity mediated by Aβ has been demonstrated to …

Background Although the advent of combination anti-retroviral therapy (cART) has
transformed HIV into a manageable chronic disease, an estimated 30–50% of people living …

We have here assessed, using Δ 9-tetrahydrocannabinol (Δ 9-THC) for comparison, the
effect of Δ 9-tetrahydrocannabinolic acid (Δ 9-THCA) and of Δ 9-tetrahydrocannabivarin (Δ9 …

Background Neurodegenerative diseases and dementia pose a global health challenge in
an aging population, exemplified by the increasing incidence and prevalence of its most …

In vitro and preclinical in vivo research in the last 35 years has clearly highlighted the crucial
physiopathological role of glial cells, namely astrocytes/microglia/oligodendrocytes and …

Given the increasing interest in bioactive dietary components that can modulate gene
expression enhancing human health, three metabolites isolated from hemp seeds …

Neuronal survival depends on the glia, that is, on the astroglial and microglial support.
Neurons die and microglia are activated not only in neurodegenerative diseases but also in …