It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and
cause neurological symptoms. Here we describe structural changes in cerebral small …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

The blood–brain barrier (BBB) restricts free access of molecules between the blood and the
brain and is essential for regulating the neural microenvironment. Here, we describe how …

The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …

Neurodegenerative and cerebrovascular diseases cause considerable human suffering,
and therapy options for these two disease categories are limited or non‐existing. It is an …

Objective Idiopathic Parkinson's disease (PD) is characterised by alpha-synuclein (aSyn)
aggregation and death of dopaminergic neurons in the midbrain. Recent evidence posits …

Endothelial progenitor cells (EPCs) have been pursued as a potential cellular therapy for
stroke and central nervous system injury. However, their underlying mechanisms remain to …

Objective Cortical spreading depolarizations (CSDs) are intense and ubiquitous
depolarization waves relevant for the pathophysiology of migraine and brain injury. CSDs …