Activation of checkpoint arrest and homologous DNA repair are necessary for maintenance
of genomic integrity during DNA replication. Germ-line mutations of the ataxia telangiectasia …

The discovery of the first gene associated with hereditary breast cancer, BRCA1, was
anticipated to greatly increase our understanding of both hereditary and sporadic forms of …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Pancreatic cancers are the fourth most-common cause of cancer-related deaths in the
Western world, with> 200,000 cases reported in 2010. Although up to 10% of these cases …

OBJECTIVE: To determine indications for the use of postmastectomy radiotherapy (PMRT)
for patients with invasive breast cancer with involved axil-lary lymph nodes or locally …

We screened individuals from 443 familial breast cancer pedigrees and 521 controls for
ATM sequence variants and identified 12 mutations in affected individuals and two in …

Background: Homozygous or compound heterozygous mutations in the ATM gene are the
principal cause of ataxia telangiectasia (AT). Several studies have suggested that …

Breast cancer poses a serious public health problem, and it is hoped that identification of
genetic and environmental factors that contribute to the development of breast cancer will …