Androgens, aging, and prostate health
K Welén, JE Damber - Reviews in Endocrine and Metabolic Disorders, 2022 - Springer
Due to late onset hypogonadism (LOH), there is an increased usage of testosterone
replacement therapy (TRT) in the aging male population. Since prostate is a target organ for …
replacement therapy (TRT) in the aging male population. Since prostate is a target organ for …
Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer
J Kallenbach, G Atri Roozbahani, M Heidari Horestani… - Cell & Bioscience, 2022 - Springer
Abstract Background Prostate cancer (PCa) is an age-related malignancy in men with a high
incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many …
incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many …
Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK/ERK1/2 pathway and resisted autophagy-related ferroptosis via AMPK/mTOR pathway …
Y Li, Y Zhou, D Liu, Z Wang, J Qiu, J Zhang… - Journal of Translational …, 2023 - Springer
Background Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly
resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 …
resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 …
A ferroptosis-related gene prognostic index associated with biochemical recurrence and radiation resistance for patients with prostate cancer undergoing radical …
D Feng, X Shi, Q Xiong, F Zhang, D Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Ferroptosis is a new type of programmed cell death which has been reported to
be involved in the development of various cancers. In this study, we attempted to explore the …
be involved in the development of various cancers. In this study, we attempted to explore the …
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
The stromal component of the tumour microenvironment in primary and metastatic prostate
cancer can influence and promote disease progression. Within the prostatic stroma …
cancer can influence and promote disease progression. Within the prostatic stroma …
A gene prognostic index from cellular senescence predicting metastasis and radioresistance for prostate cancer
D Feng, D Li, X Shi, Q Xiong, F Zhang, Q Wei… - Journal of translational …, 2022 - Springer
Background Senescent cells have been identified in the aging prostate, and the senescence-
associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we …
associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we …
The potential role of mitochondrial acetaldehyde dehydrogenase 2 in urological cancers from the perspective of ferroptosis and cellular senescence
Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote
tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with …
tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with …
An autophagy-related gene prognostic index predicting biochemical recurrence, metastasis, and drug resistance for prostate cancer
WZ Zhu, DC Feng, Q Xiong, X Shi… - Asian Journal of …, 2023 - journals.lww.com
Given the dual role of autophagy presenting in tumorigenesis and inhibition, we established
an autophagy-related gene prognostic index (ARGPI) with validation to well predict the …
an autophagy-related gene prognostic index (ARGPI) with validation to well predict the …
Immune-related gene index predicts metastasis for prostate cancer patients undergoing radical radiotherapy
In this study, we established a novel immunologic gene prognostic index (IGPI) to predict
metastasis and provided new insights into tumor immune microenvironment (TIME) for PCa …
metastasis and provided new insights into tumor immune microenvironment (TIME) for PCa …
Analysis of platelet and monocyte-to-lymphocyte ratio and diabetes mellitus with benign prostatic enlargement
G Chen, L Feng - Frontiers in Immunology, 2023 - frontiersin.org
Background The etiology of benign prostatic hyperplasia (BPH) is still elusive. The aim of
this study was to provide preventive and prognostic parameters associated with diabetes …
this study was to provide preventive and prognostic parameters associated with diabetes …