Due to late onset hypogonadism (LOH), there is an increased usage of testosterone
replacement therapy (TRT) in the aging male population. Since prostate is a target organ for …

Abstract Background Prostate cancer (PCa) is an age-related malignancy in men with a high
incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many …

Background Benign prostatic hyperplasia (BPH) is a common disease in elderly men, mainly
resulted from an imbalance between cell proliferation and death. Glutathione peroxidase 3 …

Background: Ferroptosis is a new type of programmed cell death which has been reported to
be involved in the development of various cancers. In this study, we attempted to explore the …

The stromal component of the tumour microenvironment in primary and metastatic prostate
cancer can influence and promote disease progression. Within the prostatic stroma …

Background Senescent cells have been identified in the aging prostate, and the senescence-
associated secretory phenotype might be linked to prostate cancer (PCa). Thus, we …

Overproduction of reactive oxygen species (ROS) and superlative lipid peroxidation promote
tumorigenesis, and mitochondrial aldehyde dehydrogenase 2 (ALDH2) is associated with …

Given the dual role of autophagy presenting in tumorigenesis and inhibition, we established
an autophagy-related gene prognostic index (ARGPI) with validation to well predict the …

In this study, we established a novel immunologic gene prognostic index (IGPI) to predict
metastasis and provided new insights into tumor immune microenvironment (TIME) for PCa …

Background The etiology of benign prostatic hyperplasia (BPH) is still elusive. The aim of
this study was to provide preventive and prognostic parameters associated with diabetes …