Background Understanding how cells make decisions, and why they make the decisions
they make, is of fundamental interest in systems biology. To address this, we study the …

Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically
defined medium containing two sugars (for example glucose and lactose). Typically, the two …

Microbes are capable of physiologically adapting to diverse environmental conditions by
differentially varying the rates at which they uptake different nutrients. In particular, microbes …

Modeling soil organic carbon is crucial for predicting ecosystem feedbacks to global change.
Soil C models typically divide organic C into pools with different turnover rates, even though …

When bacteria are grown in a batch culture containing a mixture of two growth-limiting
substrates, they exhibit a rich spectrum of substrate consumption patterns including diauxic …

Spirulina platensis has been considered a promising source of food supplement to combat
malnutrition worldwide. Numerous investigations have stated its immune activity, ability to …

We present three models of how transcription factors (TFs) bind to their specific binding sites
on the DNA: a model based on statistical physics, a Markov-chain model and a …

A ubiquitous tool in mathematical biology and chemical engineering, the chemostat often
produces instabilities that pose safety hazards and adversely affect the optimization of …

We develop a symbolic regression framework for extracting the governing mathematical
expressions from observed data. The evolutionary approach, faiGP, is designed to leverage …

This paper presents an efficient approach to culture medium optimization by a central
composite rotatable design (CCRD) coupled to non-linear mathematical programming …