HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment

D Saylor, AM Dickens, N Sacktor, N Haughey… - Nature Reviews …, 2016 - nature.com
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

[HTML][HTML] HIV-1-associated neurocognitive disorder: epidemiology, pathogenesis, diagnosis, and treatment

C Eggers, G Arendt, K Hahn, IW Husstedt… - Journal of …, 2017 - Springer
The modern antiretroviral treatment of human immunodeficiency virus (HIV-1) infection has
considerably lowered the incidence of opportunistic infections. With the exception of the …

Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis

Y Wang, M Liu, Q Lu, M Farrell, JM Lappin, J Shi, L Lu… - Neurology, 2020 - AAN Enterprises
Objective To characterize the prevalence and burden of HIV-associated neurocognitive
disorder (HAND) and assess associated factors in the global population with HIV. Methods …

Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study

N Sacktor, RL Skolasky, E Seaberg, C Munro… - Neurology, 2016 - AAN Enterprises
Objective: To evaluate the frequency of HIV-associated neurocognitive disorder (HAND) in
HIV+ individuals and determine whether the frequency of HAND changed over 4 years of …

[HTML][HTML] The prevalence of Frascati-criteria-based HIV-associated neurocognitive disorder (HAND) in HIV-infected adults: a systematic review and meta-analysis

J Wei, J Hou, B Su, T Jiang, C Guo, W Wang… - Frontiers in …, 2020 - frontiersin.org
Background: The HIV associated mortality is decreasing in most countries due to the
widespread use of antiretroviral therapy. However, HIV-associated neurocognitive disorder …

Controversies in HIV-associated neurocognitive disorders

S Nightingale, A Winston, S Letendre… - The Lancet …, 2014 - thelancet.com
Cross-sectional studies show that around half of individuals infected with HIV-1 have some
degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence …

Cognitive disorders in people living with HIV

A Winston, S Spudich - The Lancet HIV, 2020 - thelancet.com
High rates of cognitive disorders in antiretroviral-treated people living with HIV have been
described worldwide. The exact prevalence of such cognitive disorders is determined by the …

HIV, depression, and cognitive impairment in the era of effective antiretroviral therapy

LH Rubin, PM Maki - Current HIV/aids Reports, 2019 - Springer
Abstract Purpose of Review Mental health disorders, especially depression, are prevalent
among people living with HIV (PLWH) and are associated with cognitive impairment (CI) …

Sepsis exacerbates Alzheimer's disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden

VV Giridharan, CSG Catumbela, CHR Catalão… - Molecular …, 2023 - nature.com
While our understanding of the molecular biology of Alzheimer's disease (AD) has grown,
the etiology of the disease, especially the involvement of peripheral infection, remains a …

Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls

A Yilmaz, K Blennow, L Hagberg… - Expert review of …, 2017 - Taylor & Francis
Introduction: Several CSF biomarkers of neuronal injury have been studied in people living
with HIV. At this time, the most useful is the light subunit of the neurofilament protein (NFL) …