Digital pathology represents one of the major evolutions in modern medicine. Pathological
examinations constitute the gold standard in many medical protocols, and also play a critical …

Single-molecule biophysics has transformed our understanding of biology, but also of the
physics of life. More exotic than simple soft matter, biomatter lives far from thermal …

It is important to observe and study cancer cells' cycle progression in order to better
understand drug effects on cancer cells. Time-lapse microscopy imaging serves as an …

Breast cancer is a very common type of cancer in women around the world and more so in
India. It affects not only women but also men. In India, we have a very disturbing trend of …

The past decade has seen an unprecedented data explosion in biology. It has become
evident that in order to take full advantage of the potential wealth of information hidden in the …

Quantitative analysis of biological image data generally involves the detection of many
subresolution spots. Especially in live cell imaging, for which fluorescence microscopy is …

Quantitative analytical approaches for discovering new compound mechanisms are required
for summarizing high-throughput, image-based drug screening data. Here we present a …

Fluorescence microscopy combined with digital imaging constructs a basic platform for
numerous biomedical studies in the field of cellular imaging. As the studies relying on …

The application of high-content imaging in conjunction with multivariate clustering
techniques has recently shown value in the confirmation of cellular activity and further …

This paper provides an overview of the main aspects of modern fluorescence microscopy. It
covers the principles of fluorescence and highlights the key discoveries in the history of …