[HTML][HTML] Stress-responsive regulation of extracellular proteostasis
JS Mesgarzadeh, JN Buxbaum… - The Journal of Cell …, 2022 - ncbi.nlm.nih.gov
Genetic, environmental, and aging-related insults can promote the misfolding and
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …
subsequent aggregation of secreted proteins implicated in the pathogenesis of numerous …
Modulation of amyloid states by molecular chaperones
A Wentink… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Aberrant protein aggregation is a defining feature of most neurodegenerative diseases.
During pathological aggregation, key proteins transition from their native state to alternative …
During pathological aggregation, key proteins transition from their native state to alternative …
The extracellular protein, transthyretin is an oxidative stress biomarker
The extracellular protein, transthyretin is responsible for the transport of thyroxin and retinol
binding protein complex to the various parts of the body. In addition to this transport function …
binding protein complex to the various parts of the body. In addition to this transport function …
Regulating secretory proteostasis through the unfolded protein response: from function to therapy
L Plate, RL Wiseman - Trends in cell biology, 2017 - cell.com
Imbalances in secretory proteostasis induced by genetic, environmental, or aging-related
insults are pathologically associated with etiologically diverse protein misfolding diseases …
insults are pathologically associated with etiologically diverse protein misfolding diseases …
Chemical biology framework to illuminate proteostasis
RM Sebastian, MD Shoulders - Annual review of biochemistry, 2020 - annualreviews.org
Protein folding in the cell is mediated by an extensive network of> 1,000 chaperones, quality
control factors, and trafficking mechanisms collectively termed the proteostasis network …
control factors, and trafficking mechanisms collectively termed the proteostasis network …
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90
The critical toxic species in over 40 human diseases are misfolded proteins. Their interaction
with molecular chaperones such as Hsp90, which preferentially interacts with metastable …
with molecular chaperones such as Hsp90, which preferentially interacts with metastable …
The endoplasmic reticulum HSP 40 co‐chaperone ER dj3/DNAJB 11 assembles and functions as a tetramer
KC Chen, S Qu, S Chowdhury, IC Noxon… - The EMBO …, 2017 - embopress.org
ER dj3/DNAJB 11 is an endoplasmic reticulum (ER)‐targeted HSP 40 co‐chaperone that
performs multifaceted functions involved in coordinating ER and extracellular proteostasis …
performs multifaceted functions involved in coordinating ER and extracellular proteostasis …
Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation
MF Espinoza, KK Nguyen, MM Sycks, Z Lyu… - Journal of Biological …, 2022 - ASBMB
Most eukaryotic secretory proteins are cotranslationally translocated through Sec61 into the
endoplasmic reticulum (ER). Because these proteins have evolved to fold in the ER, their …
endoplasmic reticulum (ER). Because these proteins have evolved to fold in the ER, their …
ATF6 activation reduces amyloidogenic transthyretin secretion through increased interactions with endoplasmic reticulum proteostasis factors
JS Mesgarzadeh, IC Romine, EM Smith-Cohen… - Cells, 2022 - mdpi.com
The extracellular aggregation of destabilized transthyretin (TTR) variants is implicated in the
onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce …
onset and pathogenesis of familial TTR-related amyloid diseases. One strategy to reduce …
PERK signaling regulates extracellular proteostasis of an amyloidogenic protein during endoplasmic reticulum stress
IC Romine, RL Wiseman - Scientific reports, 2019 - nature.com
The PERK arm of the unfolded protein response (UPR) regulates cellular proteostasis and
survival in response to endoplasmic reticulum (ER) stress. However, the impact of PERK …
survival in response to endoplasmic reticulum (ER) stress. However, the impact of PERK …