Background/Objective: Skin fibrosis is the result of aberrant processes leading to abnormal
deposition of extracellular matrix (ECM) in the dermis. In healthy skin, keratinocytes …

Skin fibrosis is a physiopathological process featuring the excessive deposition of
extracellular matrix (ECM), which is the main architecture that provides structural support …

The supplementation of culture medium with fetal bovine serum (FBS, also referred to as
“fetal calf serum”) is still common practice in cell culture applications. Due to a number of …

Skin as a mechanical barrier between the inner and outer environment of our body protects
us against infection and electrolyte loss. This organ consists of 3 layers: the epidermis …

Background aims Platelet-rich plasma (PRP) has been found to contain a high concentration
of growth factors that are present during the process of healing. Studies conducted found …

Nasal mucosa injury can be caused by trauma, radiotherapy, chronic infection such as
sinusitis, and post sinus surgery. The rate of healing and its treatment are important in the …

Background Fibroblasts are ubiquitous cells in the human body and are absolutely
necessary for wound healing such as for injured skin. This role of fibroblasts was the reason …

Growth factors and extracellular matrix (ECM) proteins are involved in wound healing.
Human dermal fibroblasts secrete wound-healing mediators in culture medium known as …

Skin substitutes are one of the main treatments for skin loss, and a skin substitute that is
readily available would be the best treatment option. However, most cell-based skin …

Background Dermal fibroblasts play a pivotal role in hair follicle regeneration during wound
repair. Recently, dermal fibroblast‐conditioned medium (DFCM), which contains multi …