Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of
medicines that directly reprogramme the central dogma of biology to prevent and treat …

RNA-based gene therapy requires therapeutic RNA to function inside target cells without
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …

Over the last decade, the nanomedicine has experienced unprecedented development in
diagnosis and management of diseases. A number of nanomedicines have been approved …

Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted
into immunocompromised or humanized mice, have shown superiority in recapitulating the …

Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Cancer nanomedicines were initially envisioned as magic bullets, travelling through the
circulation to target tumours while sparing healthy tissues the toxicity of classic …

Among the many challenges in medicine, the treatment and cure of cancer remains an
outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the …

CRISPR-based drugs can theoretically manipulate any genetic target. In practice, however,
these drugs must enter the desired cell without eliciting an unwanted immune response, so …

Nanomedicines are extensively employed in cancer therapy. We here propose four strategic
directions to improve nanomedicine translation and exploitation.(1) Patient stratification has …

Conspectus mRNA drugs can preempt infectious disease and treat Mendelian disorders,
such as sickle cell anemia, muscular dystrophy, and cystic fibrosis, as well as autoimmunity …