Targeted protein degradation: A promise for undruggable proteins
KTG Samarasinghe, CM Crews - Cell chemical biology, 2021 - cell.com
Summary Protein homeostasis, or" proteostasis," is indispensable for a balanced, healthy
environment within the cell. However, when natural proteostasis mechanisms are …
environment within the cell. However, when natural proteostasis mechanisms are …
Modulation of disordered proteins with a focus on neurodegenerative diseases and other pathologies
Intrinsically disordered proteins (IDPs) do not have rigid 3D structures, showing changes in
their folding depending on the environment or ligands. Intrinsically disordered proteins are …
their folding depending on the environment or ligands. Intrinsically disordered proteins are …
Crystal structures and nuclear magnetic resonance studies of the apo form of the c-MYC: MAX bHLHZip complex reveal a helical basic region in the absence of DNA
The c-MYC transcription factor is a master regulator of cell growth and proliferation and is an
established target for cancer therapy. This basic helix–loop–helix Zip protein forms a …
established target for cancer therapy. This basic helix–loop–helix Zip protein forms a …
[HTML][HTML] Mechanistic roles of protein disorder within transcription
SL Shammas - Current opinion in structural biology, 2017 - Elsevier
Highlights•Protein disorder is highly over-represented within transcriptional
processes.•Protein disorder may accelerate binding, unbinding and/or DNA search …
processes.•Protein disorder may accelerate binding, unbinding and/or DNA search …
Targeting intrinsically disordered proteins through dynamic interactions
Intrinsically disordered proteins (IDPs) are over-represented in major disease pathways and
have attracted significant interest in understanding if and how they may be targeted using …
have attracted significant interest in understanding if and how they may be targeted using …
The topology of data: opportunities for cancer research
Motivation Topological methods have recently emerged as a reliable and interpretable
framework for extracting information from high-dimensional data, leading to the creation of a …
framework for extracting information from high-dimensional data, leading to the creation of a …
Therapeutic interventions of cancers using intrinsically disordered proteins as drug targets: c-Myc as model system
The concept of protein intrinsic disorder has taken the driving seat to understand regulatory
proteins in general. Reports suggest that in mammals nearly 75% of signalling proteins …
proteins in general. Reports suggest that in mammals nearly 75% of signalling proteins …
TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting
with Smad2-Smad4 complexes. We found that the complex structure of TGIF1–HD bound to …
with Smad2-Smad4 complexes. We found that the complex structure of TGIF1–HD bound to …
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara… - Angewandte Chemie …, 2017 - Wiley Online Library
There is a lack of current treatment options for ovarian clear cell carcinoma (CCC) and the
cancer is often resistant to platinum‐based chemotherapy. Hence there is an urgent need for …
cancer is often resistant to platinum‐based chemotherapy. Hence there is an urgent need for …
Role of backbone dynamics in modulating the interactions of disordered ligands with the TAZ1 domain of the CREB-binding protein
RB Berlow, MA Martinez-Yamout, HJ Dyson… - Biochemistry, 2019 - ACS Publications
The intrinsically disordered transactivation domains of HIF-1α and CITED2 compete for
binding of the TAZ1 domain of the CREB-binding protein by a unidirectional allosteric …
binding of the TAZ1 domain of the CREB-binding protein by a unidirectional allosteric …