DNA damage, especially DNA double strand breaks (DSBs) and replication stress, activates
a complex post-translational network termed DNA damage response (DDR). Our review …

One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …

Meiotic recombination is initiated by SPO11-induced double-strand breaks (DSBs). In most
mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the ATM kinase …

To fully exploit the potential of single-cell functional genomics in the study of development
and disease, robust methods are needed to simplify the analysis of data across samples …

During meiotic prophase I, spermatocytes must balance transcriptional activation with
homologous recombination and chromosome synapsis, biological processes requiring …

Orderly segregation of chromosomes during meiosis requires that crossovers form between
homologous chromosomes by recombination. Programmed DNA double-strand breaks …

In mammalian male meiosis, the heterologous X and Y chromosomes remain unsynapsed
and, as a result, are subject to meiotic sex chromosome inactivation (MSCI). MSCI is …

Meiotic synapsis and recombination ensure correct homologous segregation and genetic
diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which …

Meiotic sex chromosome inactivation (MSCI) is an essential process in the male germline.
While genetic experiments have established that the DNA damage response (DDR) …

In female mammals, meiotic prophase one begins during fetal development. Oocytes
transition through the prophase one substages consisting of leptotene, zygotene, and …