The goal of obesity management is to improve health. Sustained weight loss of more than
10% overall bodyweight improves many of the complications associated with obesity (eg …

Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss
of expression of maternally imprinted genes located in the paternal chromosomal region …

Prader–Willi syndrome (PWS) is a complex multisystem disorder due to the absent
expression of the paternally active genes in the PWS critical region on chromosome 15 …

Oxytocin is an important regulator of the social brain. In some animal models of autism,
notably in Magel2 tm1. 1Mus-deficient mice, peripheral administration of oxytocin in infancy …

Could nose-to-brain pathways mediate the effects of peptides such as oxytocin (OT) on brain
physiology when delivered intranasally? We address this question by contrasting two …

The development of hypothalamic obesity (HO) following craniopharyngioma (CP) and other
suprasellar tumors leads to reduced patient quality of life. No treatment algorithms are …

In recent years ample studies have reported that intranasal administration of the
neuropeptide oxytocin can facilitate social motivation and cognition in healthy and clinical …

In early childhood, individuals with Prader‐Willi syndrome (PWS) experience excess weight
gain and severe hyperphagia with food compulsivity, which often leads to early onset morbid …

The prosocial neuropeptide oxytocin is being developed as a potential treatment for various
neuropsychiatric disorders including autism spectrum disorder (ASD). Early studies using …

Advances in technologies offer new opportunities to collect and integrate data from a broad
range of sources to advance the understanding of rare diseases and support the …