Bacterial origins of human cell-autonomous innate immune mechanisms
The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …
This system comprises an array of sensors that, after detecting viral molecules, activate the …
Bacteria deplete deoxynucleotides to defend against bacteriophage infection
DNA viruses and retroviruses consume large quantities of deoxynucleotides (dNTPs) when
replicating. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the …
replicating. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the …
Phage defense origin of animal immunity
BR Morehouse - Current Opinion in Microbiology, 2023 - Elsevier
Highlights•Phage and bacterial warfare resulted in diverse immune defense
strategies.•Animals and bacteria surprisingly have many innate immune processes in …
strategies.•Animals and bacteria surprisingly have many innate immune processes in …
First Characterization of a Hafnia Phage Reveals Extraordinarily Large Burst Size and Unusual Plaque Polymorphism
L Pan, D Li, Z Sun, W Lin, B Hong, W Qin, L Xu… - Frontiers in …, 2022 - frontiersin.org
A unique lytic phage infecting Hafnia paralvei was isolated and identified. Hafnia phage Ca
belongs to the family Autographiviridae, possessing an icosahedral head with a diameter of …
belongs to the family Autographiviridae, possessing an icosahedral head with a diameter of …
Single-stranded nucleic acids bind to the tetramer interface of SAMHD1 and prevent formation of the catalytic homotetramer
KJ Seamon, NN Bumpus, JT Stivers - Biochemistry, 2016 - ACS Publications
Sterile alpha motif and HD domain protein 1 (SAMHD1) is a unique enzyme that plays
important roles in nucleic acid metabolism, viral restriction, and the pathogenesis of …
important roles in nucleic acid metabolism, viral restriction, and the pathogenesis of …
Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase
BP Klemm, D Singh, CE Smith… - Proceedings of the …, 2022 - National Acad Sciences
Levels of the cellular dNTPs, the direct precursors for DNA synthesis, are important for DNA
replication fidelity, cell cycle control, and resistance against viruses. Escherichia coli …
replication fidelity, cell cycle control, and resistance against viruses. Escherichia coli …
High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP
BP Klemm, AP Sikkema, AL Hsu, JC Horng… - Journal of Biological …, 2022 - ASBMB
Deoxynucleoside triphosphate (dNTP) triphosphohydrolases (dNTPases) are important
enzymes that may perform multiple functions in the cell, including regulating the dNTP pools …
enzymes that may perform multiple functions in the cell, including regulating the dNTP pools …
Antiviral defense via nucleotide depletion in bacteria
DNA viruses and retroviruses need to consume large quantities of deoxynucleotides
(dNTPs) when replicating within infected cells. The human antiviral factor SAMHD1 takes …
(dNTPs) when replicating within infected cells. The human antiviral factor SAMHD1 takes …
The crystal structure of dGTPase reveals the molecular basis of dGTP selectivity
Deoxynucleotide triphosphohydrolases (dNTPases) play a critical role in cellular survival
and DNA replication through the proper maintenance of cellular dNTP pools. While the vast …
and DNA replication through the proper maintenance of cellular dNTP pools. While the vast …
Structure of Ddi2, a highly inducible detoxifying metalloenzyme from Saccharomyces cerevisiae
Cyanamide (H 2 N-CN) is used to break bud dormancy in woody plants and to deter alcohol
use in humans. The biological effects of cyanamide in both these cases require the enzyme …
use in humans. The biological effects of cyanamide in both these cases require the enzyme …