The freeze-drying process is a combination of 2 equally important processes, freezing, and
drying. In the past, the effort was mainly focused on optimizing the drying process without …

Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

Assessing the viability of an amorphous formulation strategy is of great importance in an era
of drug discovery where a large percentage of new molecules have solubility limited …

Though there is an advantage in using the higher solubility amorphous state in cases where
low solubility limits absorption, physical instability poses a significant barrier limiting its use …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Objectives This review highlights aspects of drug hydrophobicity and lipophilicity as
determinants of different oral formulation approaches with specific focus on enabling …

Recrystallization of amorphous drugs is currently limiting the simple approach to improve
solubility and bioavailability of poorly water-soluble drugs by amorphization of a crystalline …

Although not readily accessible yet to many community and hospital pharmacists, fuse
deposition modelling (FDM) is a 3D printing technique that can be used to create a 3D …

Measurement of drug solubility is one of the key elements of active pharmaceutical
ingredient (API) characterization during the drug discovery and development process. This …

The effect of supersaturation on bioavailability of inhaled nebulized aerosols is compared for
amorphous versus crystalline nanoparticulate dispersions. The nanocrystalline formulations …