Role of oxidative stress in alcohol-induced liver injury
AI Cederbaum, Y Lu, D Wu - Archives of toxicology, 2009 - Springer
Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …
in small amounts during the body's metabolic reactions and can react with and damage …
Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
CS Lieber - Alcohol, 2004 - Elsevier
Liver disease in the alcoholic is due not only to malnutrition but also to ethanol's
hepatotoxicity linked to its metabolism by means of the alcohol dehydrogenase and …
hepatotoxicity linked to its metabolism by means of the alcohol dehydrogenase and …
Alcohol and cancer
G Pöschl, HK Seitz - Alcohol and alcoholism, 2004 - academic.oup.com
Epidemiological data have identified chronic alcohol consumption as a significant risk factor
for upper alimentary tract cancer, including cancer of the oropharynx, larynx and the …
for upper alimentary tract cancer, including cancer of the oropharynx, larynx and the …
[PDF][PDF] Activation of hepatic stellate cells—a key issue in liver fibrosis
HL Reeves, SL Friedman - Front Biosci, 2002 - article.imrpress.com
Introduction 3. Paracrine soluble factors regulating hepatic stellate cell activation 3.1.
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …
Transforming growth factor-beta 3.2. Tumor necrosis factor-alpha 3.3. Endothelins 3.4 …
[HTML][HTML] S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility
S-adenosyl-l-methionine (SAMe; AdoMet) is an important, metabolically pleiotropic molecule
that participates in multiple cellular reactions as the precursor for the synthesis of glutathione …
that participates in multiple cellular reactions as the precursor for the synthesis of glutathione …
[HTML][HTML] Relationships between nutrition, alcohol use, and liver disease
CS Lieber - Alcohol Research & Health, 2003 - ncbi.nlm.nih.gov
Many alcoholics are malnourished, either because they ingest too little of essential nutrients
(eg, carbohydrates, proteins, and vitamins) or because alcohol and its metabolism prevent …
(eg, carbohydrates, proteins, and vitamins) or because alcohol and its metabolism prevent …
S-adenosylmethionine synthesis: molecular mechanisms and clinical implications
JM Mato, L Alvarez, P Ortiz, MA Pajares - Pharmacology & therapeutics, 1997 - Elsevier
Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis
of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes …
of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes …
S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial
JM Mato, J Cámara, JF De Paz, L Caballería, S Coll… - Journal of …, 1999 - Elsevier
Background/Aim: The efficacy of S-adenosylmethionine (AdoMet) in the treatment of liver
cell injury has been demonstrated in several experimental models. The aim of this study was …
cell injury has been demonstrated in several experimental models. The aim of this study was …
Alcohol and the liver: 1994 update
CS Lieber - Gastroenterology, 1994 - Elsevier
This article reviews current concepts on the pathogenesis and treatment of alcoholic liver
disease. It has been known that the hepatotoxicity of ethanol results from alcohol …
disease. It has been known that the hepatotoxicity of ethanol results from alcohol …
Ethanol metabolism, cirrhosis and alcoholism
CS Lieber - Clinica chimica acta, 1997 - Elsevier
Alcohol-induced tissue damage results from associated nutritional deficiencies as well as
some direct toxic effects, which have now been linked to the metabolism of ethanol. The …
some direct toxic effects, which have now been linked to the metabolism of ethanol. The …