Oncologic photodynamic therapy: basic principles, current clinical status and future directions

D Van Straten, V Mashayekhi, HS De Bruijn, S Oliveira… - Cancers, 2017 - mdpi.com
Photodynamic therapy (PDT) is a clinically approved cancer therapy, based on a
photochemical reaction between a light activatable molecule or photosensitizer, light, and …

The physics, biophysics and technology of photodynamic therapy

BC Wilson, MS Patterson - Physics in Medicine & Biology, 2008 - iopscience.iop.org
Photodynamic therapy (PDT) uses light-activated drugs to treat diseases ranging from
cancer to age-related macular degeneration and antibiotic-resistant infections. This paper …

NIR‐II Ratiometric Chemiluminescent/Fluorescent Reporters for Real‐Time Monitoring and Evaluating Cancer Photodynamic Therapy Efficacy

L Su, Y Chen, H Huo, N Liao, Y Wu, X Ge, Z Guo… - Small, 2022 - Wiley Online Library
The development of probes for early monitoring tumor therapy response may greatly benefit
the promotion of photodynamic therapy (PDT) efficacy. Singlet oxygen (1O2) generation is a …

Photosensitized singlet oxygen generation and detection: Recent advances and future perspectives in cancer photodynamic therapy

B Li, L Lin, H Lin, BC Wilson - Journal of biophotonics, 2016 - Wiley Online Library
Photodynamic therapy (PDT) uses photosensitizers and visible light in combination with
molecular oxygen to produce reactive oxygen species (ROS) that kill malignant cells by …

Photodynamic therapy for treatment of solid tumors—potential and technical challenges

Z Huang, H Xu, AD Meyers, AI Musani… - … in cancer research …, 2008 - journals.sagepub.com
Photodynamic therapy (PDT) involves the administration of photosensitizer followed by local
illumination with visible light of specific wavelength (s). In the presence of oxygen molecules …

The role of photodynamic therapy (PDT) physics

TC Zhu, JC Finlay - Medical physics, 2008 - Wiley Online Library
Photodynamic therapy (PDT) is an emerging treatment modality that employs the
photochemical interaction of three components: light, photosensitizer, and oxygen …

Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling

KKH Wang, JC Finlay, TM Busch… - Journal of …, 2010 - Wiley Online Library
Abstract Singlet oxygen (1O2) is the major cytotoxic agent responsible for cell killing for type‐
II photodynamic therapy (PDT). An empirical four‐parameter macroscopic model is …

On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling

MM Kim, AA Ghogare, A Greer… - Physics in Medicine & …, 2017 - iopscience.iop.org
Photosensitizer photochemical parameters are crucial data in accurate dosimetry for
photodynamic therapy (PDT) based on photochemical modeling. Progress has been made …

Irradiance-dependent photobleaching and pain in δ-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas

WJ Cottrell, AD Paquette, KR Keymel, TH Foster… - Clinical cancer …, 2008 - AACR
Purpose: In superficial basal cell carcinomas treated with photodynamic therapy with topical
δ-aminolevulinic acid, we examined effects of light irradiance on photodynamic efficiency …

Photodynamic therapy (PDT) using HPPH for the treatment of precancerous lesions associated with Barrett's esophagus

HR Nava, SS Allamaneni, TJ Dougherty… - Lasers in surgery …, 2011 - Wiley Online Library
Abstract Background and Objectives Photodynamic therapy (PDT) with porfimer sodium,
FDA approved to treat premalignant lesions in Barrett's esophagus, causes photosensitivity …