This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important
regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF …

Multicellular animals match costly activities, such as growth and reproduction, to the
environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway …

Studies of neuropeptide and peptide hormone signaling are coming of age in Drosophila
due to rapid developments in molecular genetics approaches that overcome the difficulties …

The mechanisms that control the sizes of a body and its many parts remain among the great
puzzles in developmental biology. Why do animals grow to a species‐specific body size …

Queens and workers of eusocial Hymenoptera are considered homologous to the
reproductive and brood care phases of an ancestral subsocial life cycle. However, the …

In metazoans, tissue growth relies on the availability of nutrients—stored internally or
obtained from the environment—and the resulting activation of insulin/IGF signaling (IIS). In …

The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a
crucial role in the regulation of metabolism, growth and development, fecundity, stress …

Significant progress has been achieved in silkworm (Bombyx mori) research since the last
review on this insect was published in this journal in 2005. In this article, we review the new …

Members of the insulin family of peptides have conserved roles in the regulation of growth
and metabolism in a wide variety of metazoans. Here we show that Drosophila insulin-like …