Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Introduction The intestinal microbiota comprises bacteria, fungi, archaea, protists, helminths
and viruses that symbiotically inhabit the digestive system. To date, research has provided …

Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally
affects individuals with obesity. The mechanisms by which obesity leads to the onset and …

Recent years have witnessed significant increase in both fundamental and clinical studies
evaluating DDS for osteoarthritis. Steroid encapsulating polymeric microparticles for longer …

Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro
human cell‐derived microphysiological system capable of simulating intraarticular tissue …

Osteoarthritis (OA) is a painful and disabling disease that affects millions of people
worldwide. Symptom-alleviating treatments exist, although none with long-term efficacy …

Disorders of the synovial joint, such as osteoarthritis (OA) and rheumatoid arthritis (RA),
afflict a substantial proportion of the global population. However, current clinical …

Objective Body weight change and obesity follow the variance of excess energy input
balanced against tightly controlled EE (energy expenditure). Since insulin resistance can …

Extensive preclinical data support the use of intra-articular gene therapy for treating OA.
Translation is beginning to accelerate and six gene therapeutics are in clinical trials …

The CRISPR/Cas system has emerged as a powerful tool for genome editing in metabolic
engineering and human gene therapy. However, locating the optimal site on the …