Chemokines play crucial roles in combating microbial infection and initiating tissue repair by
recruiting neutrophils in a timely and coordinated manner. In humans, no less than seven …

Address reprint requests to Barrett J. Rollins, MD, PhD, Dana-kines than humans (for
example, there is no clear-cut murine Farber Cancer Institute, 44 Binney St, Boston, MA …

Interleukin 8, the first chemokine to be characterized, was discovered nearly ten years ago.
Today, more than 30 human chemokines are known. They are often upregulated in …

Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

The understanding of molecular recognition processes of small ligands and biological
macromolecules requires a complete characterization of the binding energetics and …

Protein–protein complexes that dissociate and associate readily, often depending on the
physiological condition or environment, play an important role in many biological processes …

Fifteen years have passed since the first description of interleukin (IL)-8/CXCL8 as a potent
neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types …

Chemokines are 8− 10 kDa proteins involved in the control of leukocyte trafficking and
activation. In free solution, chemokines are monomers at physiologic concentrations …

In the last two decades, isothermal titration calorimetry (ITC) has become the preferred
technique to determine the binding energetics of biological processes, including protein …

Structural analysis of chemokines has revealed that the α/β structural‐fold is highly
conserved among both the CXC and CC chemokine classes. Although dimerization and …