Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical
drawback as each disease interferes with the treatment of the other. In addition to shared …

The heart has a high rate of ATP production and turnover that is required to maintain its
continuous mechanical work. Perturbations in ATP-generating processes may therefore …

Elevated levels of branched-chain amino acids (BCAAs) have recently been implicated in
the development of cardiovascular and metabolic diseases, but the molecular mechanisms …