Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …

The growth of cancer tissue is thought to be considered driven by a small subpopulation of
cells, so-called cancer stem cells (CSCs). CSCs are located at the apex of a hierarchy in a …

The mechanisms of initiation of pancreatic ductal adenocarcinoma (PDAC) are still largely
unknown. In the present study, we analysed the role of anterior gradient-2 (AGR2) in the …

Background & Aims Oncogenic Kras G12D induces neoplastic transformation of pancreatic
acinar cells through acinar-to-ductal metaplasia (ADM), an actin-based morphogenetic …

Background Several reports have shown the role of glycosylation in pancreatic cancer (PC),
but a global systematic screening of specific glycosyltransferases (glycoTs) in its …

Background: The aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a key
enzyme associated with a variety of metabolic processes, including glucose metabolism. We …

Introduction Hypoxia is one of the important reasons for the poor therapeutic efficacy of
current pancreatic cancer treatment, and the dense stroma of pancreatic cancer restricts the …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor
prognosis. Our previous study found that peroxisome proliferator activated receptor gamma …

Oncogenic KRAS activation, inflammation and p53 mutation are key drivers of pancreatic
cancer (PC) development. Here we report iASPP, an inhibitor of p53, as a paradoxical …

Persistent acinar to ductal metaplasia (ADM) is a recently recognized precursor of
pancreatic ductal adenocarcinoma (PDAC). Here we show that the ADM area of human …