Biomarker-targeted therapies for advanced-stage gastric and gastro-oesophageal junction cancers: an emerging paradigm

Y Nakamura, A Kawazoe, F Lordick… - Nature reviews Clinical …, 2021 - nature.com
Advances in cancer biology and sequencing technology have enabled the selection of
targeted and more effective treatments for individual patients with various types of solid …

[HTML][HTML] HER2 testing in gastric cancer: An update

LF Abrahao-Machado… - World Journal of …, 2016 - ncbi.nlm.nih.gov
Human epidermal growth factor receptor 2 (HER2) overexpression is increasingly
recognized as a frequent molecular abnormality in gastric and gastroesophageal cancer …

Lapatinib Plus Paclitaxel Versus Paclitaxel Alone in the Second-Line Treatment of HER2-Amplified Advanced Gastric Cancer in Asian Populations: TyTAN—A …

T Satoh, RH Xu, HC Chung, GP Sun, T Doi… - Journal of clinical …, 2014 - ascopubs.org
Purpose In Asian countries, paclitaxel once per week is used as second-line treatment in
advanced gastric cancer, including human epidermal growth factor receptor 2 (HER2) …

The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

MM Moasser - Oncogene, 2007 - nature.com
The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Assessment of a HER2 scoring system for gastric cancer: results from a validation study

M Hofmann, O Stoss, D Shi, R Büttner… - …, 2008 - Wiley Online Library
Aims: Human epidermal growth factor receptor 2 (HER2) overexpression/amplification is
implicated in the development of various solid tumour types. Validated methods and scoring …

[HTML][HTML] HER2-positive gastric cancer

N Boku - Gastric cancer, 2014 - Springer
Human epidermal growth factor receptor 2 (HER2) is involved in the pathogenesis and poor
outcomes of several types of cancer, including advanced gastric and gastroesophageal …

[HTML][HTML] HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing

J Rüschoff, M Dietel, G Baretton, S Arbogast, A Walch… - Virchows Archiv, 2010 - Springer
Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-
positive patients with advanced gastric cancer in a large multicentric trial (ToGA study) …

[HTML][HTML] An organoid-based preclinical model of human gastric cancer

NG Steele, J Chakrabarti, J Wang, J Biesiada… - Cellular and molecular …, 2019 - Elsevier
Background & Aims Our goal was to develop an initial study for the proof of concept whereby
gastric cancer organoids are used as an approach to predict the tumor response in …

[HTML][HTML] Clinical practice guidelines for gastric cancer in Korea: an evidence-based approach

JH Lee, JG Kim, HK Jung, JH Kim… - Journal of gastric …, 2014 - synapse.koreamed.org
Although gastric cancer is quite common in Korea, the treatment outcome is relatively
favorable compared to those in western countries. However, there are currently no Korean …

[HTML][HTML] Targeted therapies for gastric cancer: failures and hopes from clinical trials

M Apicella, S Corso, S Giordano - Oncotarget, 2017 - ncbi.nlm.nih.gov
Gastric cancer is the third leading cause of cancer mortality worldwide. As surgery is the only
curative treatment strategy and conventional chemotherapy has shown limited efficacy-with …