Over the last two decades, improved access to human islets and the development of human
islet distribution networks have enabled the use of millions of human islets in hundreds of …

Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of
C-peptide long after disease onset but develop an inadequate glucagon response to …

Abstract The Network for Pancreatic Organ donors with Diabetes (nPOD) is the largest
biorepository of human pancreata and associated immune organs from donors with type 1 …

OBJECTIVE Pancreas size is reduced in patients at type 1 diabetes onset and in
autoantibody (AAB)-positive donors without diabetes. We sought to determine whether …

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a
33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β …

The KCNJ11 gene encodes the Kir6. 2 subunit of the adenosine triphosphate‐sensitive
potassium (KATP) channel, which plays a key role in insulin secretion. Monogenic diseases …

The HNF1α p291fsinsC truncation is the most common mutation associated with maturity-
onset diabetes of the young 3 (MODY3). Although shown to impair HNF1α signaling, the …

Aims Misclassification of diabetes is common due to an overlap in the clinical features of
type 1 and type 2 diabetes. Combined diagnostic models incorporating clinical and …

Background: Maturity-onset diabetes of the young (MODY) is the most common monogenic
diabetes. The aim of this study was to assess the prevalence of MODY in phenotypic type 2 …

Histopathology based studies of the pancreas obtained from organ donors are increasing
our awareness of islet phenotypic heterogeneity during development and aging, as well as …