Blocked cellular differentiation is a central pathologic feature of the myeloid malignancies,
myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Treatment regimens …

This review highlights new findings that have deepened our understanding of the
mechanisms of leukemogenesis, therapy and resistance in acute promyelocytic leukemia …

Background: Smooth muscle cells (SMCs) play significant roles in atherosclerosis via
phenotypic switching, a pathological process in which SMC dedifferentiation, migration, and …

Abstract Acute Promyelocytic Leukemia (APL) is characterized by a block in differentiation
where leukemic cells are halted at the promyelocyte stage. A characteristic balanced …

Abstract The Cytochrome P450 (CYP) family 26 enzymes contribute to retinoic acid (RA)
metabolism and homeostasis in humans, mammals and other chordates. The three CYP26 …

The transformation of acute promyelocytic leukemia (APL) from an often fatal to highly
curable cancer with long-term survival exceeding 90% is one of the greatest and most …

Objective To provide an overview of acute leukemia, comparing incidence, presenting
symptoms, diagnosis, prognosis, and treatment of the major subtypes. Data Sources Review …

The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a
regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been …

Co-encapsulation of retinoic acid (RA), curcumin and/or resveratrol into microparticles
composed by alginic acid sodium and the ethyl cellulose+ polyethylene glycol (EC+ PEG) …

With the recent description of the molecular and cellular characteristics that enable
acquisition of both core and new hallmarks of cancer, the consequences of transcription …