Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

A variety of cell types in pulmonary arteries (endothelial cells, fibroblasts, and smooth
muscle cells) are continuously exposed to mechanical stimulations such as shear stress and …

Transient receptor potentials (TRPs) are non-selective cation channels that are widely
expressed in vascular beds. They contribute to the Ca2+ influx evoked by a wide spectrum …

Background and Purpose Tetramethylpyrazine (TMP) was originally isolated from the
traditional Chinese herb ligusticum and the fermented Japanese food natto and has since …

Breast microcalcification is a potential diagnostic indicator for non-palpable breast cancers.
Microcalcification type I (calcium oxalate) is restricted to benign tissue, whereas type II …

Aims Previously we demonstrated that both hypoxia inducible factor-1 (HIF-1) and bone
morphogenetic protein-4 (BMP4) up-regulate transient receptor potential canonical (TRPC) …

The transient receptor potential (TRP) channel superfamily is a group of non-selective cation
channels functioning as cellular sensors for a wide range of physical, chemical and …

Bone morphogenetic protein-4 (BMP4), a member of the transforming growth factor β (TGF-
β) family of growth factors, is activated and increased under hypoxic conditions, which plays …

Pulmonary hypertension (PH) develops in 30-70% of chronic obstructive pulmonary disease
patients and increases morbidity and mortality. The present study aimed to investigate the …

Bone morphogenetic protein‐4 (BMP4) plays a crucial role in carcinogenesis, but the effects
and signaling mechanisms of BMP4 in hepatocellular carcinoma (HCC) are not clearly …