[HTML][HTML] Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

SW Ferguson, J Wang, CJ Lee, M Liu… - Scientific reports, 2018 - nature.com
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of
diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite …

Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system

M Segarra, MR Aburto, F Cop, C Llaó-Cid, R Härtl… - Science, 2018 - science.org
INTRODUCTION The function of the brain relies on communication among the complex
network of cells that constitute this organ. Vascularization of the central nervous system …

Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF–NMDAR pathways in a rat model of vascular …

N Zhang, M Xing, Y Wang, H Tao, Y Cheng - Neuroscience, 2015 - Elsevier
This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation
(rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze …

Angiogenesis in the pathophysiology of schizophrenia—a comprehensive review and a conceptual hypothesis

R Lopes, R Soares, R Coelho, M Figueiredo-Braga - Life sciences, 2015 - Elsevier
Schizophrenia (SZ) is a severe mental disorder poorly elucidated from the etiopathogenesis
prism. Recently, several micro-and macro-vascular abnormalities have been consistently …

Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease

Y Li, DW Wang, Y Chen, C Chen, J Guo… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—The genetic contribution to coronary artery disease (CAD) remains largely
unclear. We combined genetic screening with functional characterizations to identify novel …

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the …

Y Yamakage, M Kato, A Hongo, H Ogino, K Ishii… - Molecular and Cellular …, 2019 - Elsevier
Reelin plays important roles in regulating neuronal development, modulating synaptic
function, and counteracting amyloid β toxicity. A specific proteolytic cleavage (Nt cleavage) …

Mechanism of Rhizoma Coptidis in epilepsy with network pharmacology

D Huang, Y Lv, C Lu, B Zhang, Z Fu… - Allergologia et …, 2022 - all-imm.com
Network pharmacology is a bioinformatics-based research strategy aimed at identifying drug
actions and facilitating drug discovery. In this study, network pharmacology was used for …

Reversal of ApoE4-driven brain pathology by vascular endothelial growth factor treatment

S Salomon-Zimri, MJ Glat, Y Barhum… - Journal of …, 2016 - content.iospress.com
Abstract Apolipoprotein E4 (ApoE4), the most prevalent genetic risk factor for Alzheimer's
disease (AD), is associated with increased neurodegeneration and vascular impairments …

Ubiquitin-proteasome dependent degradation of GABAAα1 in autism spectrum disorder

A Crider, CD Pandya, D Peter, AO Ahmed, A Pillai - Molecular autism, 2014 - Springer
Background Although the neurobiological basis of autism spectrum disorder (ASD) is not
fully understood, recent studies have indicated the potential role of GABA A receptors in the …