Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Neglected tropical diseases (NTDs) as termed by WHO include twenty different infectious
diseases that are caused by bacteria, viruses, and parasites. Among these NTDs, Chagas …

Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

A critical review of the development of specific chemotherapeutic approaches for the
management of American Trypanosomiasis or Chagas disease is presented, including …

Present knowledge on peroxiredoxins is reviewed with special emphasis on catalytic
principles, specificities and biological function. Peroxiredoxins are low efficiency …

We have analyzed structure‐sequence relationships in 32 families of flavin adenine
dinucleotide (FAD)‐binding proteins, to prepare for genomic‐scale analyses of this family …

Carbon-oxygen (CH··· O) hydrogen bonding represents an unusual category of molecular
interactions first documented in biological structures over 4 decades ago. Although CH··· O …

Leishmaniasis is a disease that affects 2 million people and kills 70000 persons every year.
It is caused by Leishmania species, which are human protozoan parasites of the …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …