[HTML][HTML] Brain renin–angiotensin system at the intersect of physical and cognitive frailty

C Cosarderelioglu, LS Nidadavolu… - Frontiers in …, 2020 - frontiersin.org
The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis

C Custodero, A Ciavarella, F Panza, D Gnocchi… - Geroscience, 2022 - Springer
Vascular contribution to cognitive impairment and dementia (VCID) is a clinical label
encompassing a wide range of cognitive disorders progressing from mild to major vascular …

[HTML][HTML] Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury

M Oz, DE Lorke - Biomedicine & Pharmacotherapy, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a pandemic affecting
millions of individuals has raised great concern throughout the world, and the severe acute …

[HTML][HTML] Cognitive impairment in heart failure: landscape, challenges, and future directions

M Yang, D Sun, Y Wang, M Yan, J Zheng… - Frontiers in …, 2022 - frontiersin.org
Heart failure (HF) is a major global health-care problem accounting for substantial
deterioration of prognosis. As a complex clinical syndrome, HF often coexists with multi …

Cognitive impairment in myocardial infarction and heart failure

K Jinawong, N Apaijai, N Chattipakorn… - Acta …, 2021 - Wiley Online Library
Myocardial infarction (MI) occurs when coronary blood flow is decreased due to an
obstruction/occlusion of the vessels, leading to myocardial death and progression to heart …

Hypertension and age-related cognitive impairment: common risk factors and a role for precision aging

M Hay, C Barnes, M Huentelman, R Brinton… - Current Hypertension …, 2020 - Springer
Abstract Purpose of Review Precision Aging® is a novel concept that we have recently
employed to describe how the model of precision medicine can be used to understand and …

Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice

JA Blackwell, JF Silva, EM Louis… - American Journal …, 2022 - journals.physiology.org
Cognitive decline is linked to decreased cerebral blood flow, particularly in women after
menopause. Impaired cerebrovascular function precedes the onset of dementia, possibly …

Glycopeptide drugs: A pharmacological dimension between “Small Molecules” and “Biologics”

CR Apostol, M Hay, R Polt - Peptides, 2020 - Elsevier
Peptides are an important class of molecules with diverse biological activities. Many
endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in …

[HTML][HTML] Angiotensin-(1-7)/MasR axis promotes migration of monocytes/macrophages with a regulatory phenotype to perform phagocytosis and efferocytosis

I Zaidan, LP Tavares, MA Sugimoto, KM Lima… - JCI insight, 2022 - ncbi.nlm.nih.gov
Nonphlogistic migration of macrophages contributes to the clearance of pathogens and
apoptotic cells, a critical step for the resolution of inflammation and return to homeostasis …

Angiotensin (1–7) delivered orally via probiotic, but not subcutaneously, benefits the gut-brain axis in older rats

TW Buford, Y Sun, LM Roberts, A Banerjee… - Geroscience, 2020 - Springer
To (1) investigate the efficacy of multiple doses of an orally delivered probiotic bacteria
Lactobacillus paracasei (LP) modified to express angiotensin (1–7)(LP-A) in altering …