Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which
can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti …

Simple Summary The rapid development of diagnostic and therapeutic methods of the
cancer treatment causes that these diseases are becoming better known and the fight …

A series of twenty one compounds with pyrazole and oxindole conjugates were synthesized
by Knoevenagel condensation and investigated for their antiproliferative activity on different …

Abstract Sets of 3-alkenyl-2-oxindoles (6, 10, 13) were synthesized in a facile synthetic
pathway through acid dehydration (EtOH/HCl) of the corresponding 3-hydroxy-2 …

Neuroinflammation, in particular activation of microglia, is thought to play an important role
in the progression of neurodegenerative diseases. In activated microglia, the purinergic …

Background Angiogenesis is a process of formation of new blood vessels and is an
important criteria demonstrated by cancer cells. Over a period of time, these cancer cells …

Abstract A series of 1, 4-dihydroindeno-[1, 2-c] pyrazole linked oxindole conjugates have
been synthesized by using Knoevenagel condensation method and further evaluated for …

Glioblastoma (GB) remains the most fatal brain tumor characterized by a high infiltration rate
and treatment resistance. Overexpression and/or mutation of receptor tyrosine kinases is …

Abstract α-β unsaturated heterocyclic compounds such as C3-arylidene-oxindoles, with five-
member rings containing nitrogen, have an important role in the realm of medicine. This …

Inhibition of the VEGF signaling pathway has become a valuable approach in the treatment
of cancers. In this work, a series of N-(2-phenyl-1H-benzo [d] imidazol-5-yl) quinolin-4-amine …