Dysregulation of glutathione homeostasis and alterations in glutathione-dependent enzyme
activities are increasingly implicated in the induction and progression of neurodegenerative …

Bile acids (BA) are amphipathic steroid acids synthesized from cholesterol in the liver. They
act as detergents to expedite the digestion and absorption of dietary lipids and lipophilic …

Excess production of reactive oxygen species in the brain has been implicated as a common
underlying risk factor for the pathogenesis of a number of neurodegenerative disorders …

Therapeutic strategies for the fatal neurodegenerative disease amyotrophic lateral sclerosis
(ALS) have not yet provided satisfactory results. Interest in stem cells for the treatment of …

Amyotrophic lateral sclerosis (ALS) is an adult‐onset neurodegenerative disease
characterized by the selective death of upper and lower motor neurons which ultimately …

The amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized
by motoneurons death. Mutations in the superoxide dismutase 1 (SOD1) protein have been …

Amyotrophic lateral sclerosis (ALS) is a rare neurological disorder that affects the motor
neurons responsible for regulating muscle movement. However, the molecular pathogenic …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting
both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple …

The ganglioside-induced differentiation-associated protein 1 (GDAP1) is a mitochondrial
fission factor and mutations in GDAP1 cause Charcot–Marie–Tooth disease. We found that …

Objectives Mitochondrial oxidative stress (MOS) is a major factor in the underlying pathology
of many neurodegenerative diseases. Here, we investigated the neuroprotective effects of a …