Transcriptomic characterization revealed that METTL7A inhibits melanoma progression via the p53 signaling pathway and immunomodulatory pathway

D Zhang, T Zou, Q Liu, J Chen, M Xiao, A Zheng… - PeerJ, 2023 - peerj.com
ABSTRACT METTL7A is a protein-coding gene expected to be associated with methylation,
and its expression disorder is associated with a range of diseases. However, few research …

Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue

HN Huang, CW Kuo, YL Hung, CH Yang, YH Hsieh… - Scientific Reports, 2024 - nature.com
Assessing programmed death ligand 1 (PD-L1) expression through immunohistochemistry
(IHC) is the golden standard in predicting immunotherapy response of non-small cell lung …

[HTML][HTML] Lack of TGFβ signaling competency predicts immune poor cancer conversion to immune rich and response to checkpoint blockade

J Moore, J Gkantalis, I Guix, W Chou, K Yuen, AA Lazar… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Background: Transforming growth factor beta (TGFβ) is well-recognized as an
immunosuppressive player in the tumor microenvironment but also has a significant impact …

Lack of TGFβ signaling competency predicts conversion of immune poor cancer to immune rich and response to checkpoint blockade.

J Moore, J Gkantalis, I Guix, W Chou… - Biorxiv: the Preprint …, 2024 - europepmc.org
Background Transforming growth factor beta (TGFβ) is well-recognized as an
immunosuppressive player in the tumor microenvironment but also has a significant impact …