Structural dynamics in chromatin unraveling by pioneer transcription factors
A Orsetti, D van Oosten, RG Vasarhelyi… - Biophysical …, 2024 - Springer
Pioneer transcription factors are proteins with a dual function. First, they regulate
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …
transcription by binding to nucleosome-free DNA regulatory elements. Second, they bind to …
Structural and dynamic studies of chromatin by solid-state NMR spectroscopy
CP Jaroniec - Current Opinion in Structural Biology, 2024 - Elsevier
Chromatin is a complex of DNA with histone proteins organized into nucleosomes that
regulates genome accessibility and controls transcription, replication and repair by …
regulates genome accessibility and controls transcription, replication and repair by …
[HTML][HTML] Unveiling structural and dynamical features of chromatin using NMR spectroscopy
X Shi - Magnetic Resonance Letters, 2024 - Elsevier
Eukaryotic deoxyribonucleic acid (DNA) is wrapped around histone octamers (HOs) to form
nucleosome core particles (NCPs), which in turn interact with linker DNA and linker histones …
nucleosome core particles (NCPs), which in turn interact with linker DNA and linker histones …
Investigating Different Dynamic pHP1α States in Their KCl-Mediated Liquid–Liquid Phase Separation (LLPS) Using Solid-State NMR (SSNMR) and Molecular …
SY Chin, Y Chen, L Zhao, X Liu, CP Chng… - The Journal of …, 2024 - ACS Publications
Chromatin phase separation is dynamically regulated by many factors, such as post-
translational modifications and effector proteins, and plays a critical role in genomic …
translational modifications and effector proteins, and plays a critical role in genomic …
[HTML][HTML] From molecular descriptions to cellular functions of intrinsically disordered protein regions
Molecular descriptions of intrinsically disordered protein regions (IDRs) are fundamental to
understanding their cellular functions and regulation. NMR spectroscopy has been a leading …
understanding their cellular functions and regulation. NMR spectroscopy has been a leading …
Capturing the Conformational Heterogeneity of HSPB1 Chaperone Oligomers at Atomic Resolution
RF Berkeley, AP Plonski, T Phan, K Grohe, L Becker… - bioRxiv, 2024 - biorxiv.org
Small heat shock proteins (sHSPs), including HSPB1, are essential regulators of cellular
proteostasis that interact with unfolded and partially folded proteins to prevent aberrant …
proteostasis that interact with unfolded and partially folded proteins to prevent aberrant …
HP1α-driven Phase Separation and Repair Pathway Choice in Response to Heterochromatin Damage
D Bohra, A Mazumder - bioRxiv, 2024 - biorxiv.org
Double-strand breaks (DSBs) pose significant threat to genomic stability and need
immediate attention from DNA Damage Response (DDR) machinery involved in …
immediate attention from DNA Damage Response (DDR) machinery involved in …